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PhD position offer: Dual inhibitor design for inflammatory processes

A PhD position is open for applications for a 36-month PhD contract at La Rochelle Université as part of an EU-funded interdisciplinary project on inflammation and cancer, in collaboration with the University of Calgary (Canada) and MolDrug AI Systems (Spain). The project aims to develop novel dual inhibitors targeting two key enzymes: Heparanase 1 (HPSE1) and Membrane-Type Matrix Metalloproteinase 1 (MT1-MMP), involved in macrophage regulation and inflammatory responses.

Project overview

  • Research focus:
    • Drug design & synthesis: Create and optimize bio-inspired small molecules (<400 Da) using computational methods, QSAR, and structure-based design.
    • Mechanistic studies: Investigate how HPSE1 and MT1-MMP regulate macrophage polarization via enzymatic cleavage of HSPGs, employing in vitro assays, cell-based experiments, and advanced proteomics.
    • Therapeutic validation: Assess the potential of these dual inhibitors as cost-effective anti-inflammatory agents.
  • Collaborative framework:
    • La Rochelle Université (France): Expertise in chemical synthesis and bio-inspired molecule development.
    • University of Calgary (Canada): Advanced proteomics, N-terminomics, and bioinformatics.
    • MolDrug AI Systems (Spain): Specialization in molecular docking and structure-based drug design.

 

Candidate profile

  • Educational background: Master’s degree in chemistry, biochemistry, or a related field.
  • Technical skills & interests: A strong foundation in drug discovery techniques, mass spectrometry, proteomics, bioinformatics, and cell biology.
  • Mobility requirement: Must comply with the Marie Sklodowska-Curie mobility rule.
  • Inclusivity: Open to candidates with a Qualified Health and Disability certificate (RQTH).

 

Training & timeline highlights

  • Interdisciplinary training: Gain hands-on experience in molecular docking, chemical synthesis, bioinformatics, and advanced analytical techniques through a structured program across partner institutions.
  • Phased learning:
    • Introductory courses in synthesis and biological techniques at La Rochelle.
    • Specialized training in computational drug design and bioinformatics with MolDrug AI Systems.
    • Advanced proteomics and analytical methods at the University of Calgary.

 

Benefits & application process

  • Location: La Rochelle Université, France
  • Salary: €2700 gross per month
  • Application Deadline: 15 March 2025
  • Required Documents: Resume/CV, cover letter, proof of identity, Master’s transcript, and completed application form (all in English)
  • Contact: eudocs_cofund@univ-lr.fr

 

🔗 For more details and the complete application process, please visit the Euraxess Job Portal. (https://euraxess.ec.europa.eu/jobs/308642)

📧 For any inquiries, please contact: eudocs_cofund@univ-lr.fr.